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Fetal Effects of Anticonvulsant Polytherapies Arch Neurol 68:1273-1279, Holmes, L.et al, 2011 See this aricle in Pubmed Article Abstract The risk of malformations among infants exposed to lamotrigine and carbamazepine as polytherapy was higher than the corresponding monotherapies only when the polytherapy includes valproate. These findings suggest that counseling for fetal risks from AED polytherapy should be based on the specific drugs included.

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